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cafs  (Miltenyi Biotec)


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    Miltenyi Biotec cafs
    Cafs, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 94/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cafs/product/Miltenyi Biotec
    Average 94 stars, based on 2 article reviews
    cafs - by Bioz Stars, 2026-03
    94/100 stars

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    Image Search Results


    Talabostat mesylate reverses CRLM progression and synergizes with PD-1/PD-L1 blockade therapy. A, Schematic of the subcutaneous mouse model established with MC38 cells. B–D, Representative tumor morphology, weight, and volume ( n = 5 mice/group). E, ELISA measured the IFNγ, granzyme B, and TGFβ levels in the tumor tissues. F, Schematic representation of the colorectal cancer (CRC) PDX model in PBMC-reconstituted NOG mice. G–I, Tumor morphology, weight, and volume data ( n = 5 mice/group). J, ELISA measured the SPP1, IFNγ, granzyme B, and TGFβ levels in the tumor tissues. K and L, Hematoxylin and eosin staining of metastatic livers from C57BL/6J mice implanted with MC38-GFP or MC38-SPP1 cells, treated with talabostat mesylate, showed liver weight and tumor burden ( n = 5 mice/group). Scale bar, 1 mm. M and N, Flow cytometric analysis of the IFNγ + CD8 + and GZMB + CD8 + T-cell populations in liver metastases ( n = 5 mice/group). Results are presented as mean ± SEM. P values were determined via one-way ANOVA ( D , E , H , J , and L–N ). *, P < 0.05; **, P < 0.01; ***, P < 0.001. aP, anti–PD-1 antibody; aP + i, anti–PD-1 antibody + talabostat mesylate.

    Journal: Cancer Research

    Article Title: SPP1 Drives Colorectal Cancer Liver Metastasis and Immunotherapy Resistance by Stimulating CXCL12 Production in Cancer-Associated Fibroblasts

    doi: 10.1158/0008-5472.CAN-24-4916

    Figure Lengend Snippet: Talabostat mesylate reverses CRLM progression and synergizes with PD-1/PD-L1 blockade therapy. A, Schematic of the subcutaneous mouse model established with MC38 cells. B–D, Representative tumor morphology, weight, and volume ( n = 5 mice/group). E, ELISA measured the IFNγ, granzyme B, and TGFβ levels in the tumor tissues. F, Schematic representation of the colorectal cancer (CRC) PDX model in PBMC-reconstituted NOG mice. G–I, Tumor morphology, weight, and volume data ( n = 5 mice/group). J, ELISA measured the SPP1, IFNγ, granzyme B, and TGFβ levels in the tumor tissues. K and L, Hematoxylin and eosin staining of metastatic livers from C57BL/6J mice implanted with MC38-GFP or MC38-SPP1 cells, treated with talabostat mesylate, showed liver weight and tumor burden ( n = 5 mice/group). Scale bar, 1 mm. M and N, Flow cytometric analysis of the IFNγ + CD8 + and GZMB + CD8 + T-cell populations in liver metastases ( n = 5 mice/group). Results are presented as mean ± SEM. P values were determined via one-way ANOVA ( D , E , H , J , and L–N ). *, P < 0.05; **, P < 0.01; ***, P < 0.001. aP, anti–PD-1 antibody; aP + i, anti–PD-1 antibody + talabostat mesylate.

    Article Snippet: Additionally, the β-catenin inhibitor MSAB (cat. #HY-120697) and the CAF inhibitor talabostat (cat. #HY-13233) were sourced from MedChemExpress.

    Techniques: Enzyme-linked Immunosorbent Assay, Staining